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Alcohol & Buprenorphine (Narcotic) is Unsafe

  • Barbara Hoefener NP
  • Jun 25
  • 1 min read

Alcohol and buprenorphine/ Narcotic together can significantly depress your central nervous system (CNS), leading to potentially life-threatening effects.


1. Respiratory Depression

Buprenorphine is a partial opioid agonist. It can suppress breathing, especially in high doses or when combined with other depressants.

Alcohol is also a CNS depressant and slows breathing.

Together, they amplify each other's effects, making it much more likely for breathing to slow down or stop entirely — a major cause of fatal overdoses.


2. Sedation and Loss of Consciousness

Both substances cause drowsiness and impaired motor function.

Mixing them can lead to deep sedation, blackouts, or coma.


3. Increased Risk of Overdose

Even small amounts of alcohol can dramatically increase the sedative effects of buprenorphine.

Since buprenorphine has a ceiling effect for euphoria and respiratory depression on its own, people may underestimate the risk when mixing it with alcohol — but the interaction overrides this safety buffer.


4. Impaired Judgment and Coordination

Mixing the two can severely impair decision-making, increasing the risk of accidents, falls, or risky behaviors (like driving under the influence).


5. Liver Stress

Both substances are processed by the liver. Long-term combined use can increase liver damage risk, especially in people with existing liver issues.


In Summary:

Combining alcohol and buprenorphine can result in fatal respiratory depression, coma, or overdose. This combination should always be avoided.


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